The reference site for Mupirocin

Mupirocin, sold under the brand name Bactroban among others, is a topical antibiotic useful against superficial skin infections such as impetigo or folliculitis.

WHAT IS Mupirocin?

Mupirocin, an antibiotic, is used to treat impetigo as well as other skin infections caused by bacteria.  It is not effective, however, against fungal or viral infections.

Unlike other antibiotics which act on either bacterial DNA or the cellular walls of bacteria, mupirocin blocks the activity of an enzyme called isoleucyl-tRNA synthetase within the bacteria. This enzyme is necessary in order for the bacteria to make proteins. Without the ability to make proteins, the bacteria dies.

 

Brand Name(s): Bactroban, Centany
CAS nº: 12650-69-0
(myoo peer’ oh sin)

 

Product Info

The sections below will provide you with more specific information and guidelines related to mupirocin and its correct use. Please read them carefully.

FDA Information

Mupirocin topical cream was approved by the FDA in December 1987. The intranasal form was approved October 1995.

A prescription is required for this medicine.

Why is this medication prescribed?

Mupirocin, an antibiotic, is used to treat impetigo as well as other skin infections caused by bacteria.  It is not effective against fungal or viral infections.

Unlike other antibiotics which act on either bacterial DNA or the cellular walls of bacteria, mupirocin blocks the activity of an enzyme called isoleucyl-tRNA synthetase within the bacteria. This enzyme is necessary in order for the bacteria to make proteins. Without the ability to make proteins, the bacteria dies.

Other uses for this medicine

This medication has not been approved for any alternative uses other than those mentioned in the product information section.

Dosage and using this medicine

Mupirocin topical:

Take mupirocin topical exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Wash your hands before and after using this medication.

Clean and dry the affected area. Apply a small amount of the ointment as directed.

Use this medication for the full amount of time prescribed by your doctor or as recommended in the package even if you begin to feel better. Your symptoms may improve before the infection is completely healed.

You should notice improvement in 3 to 5 days. If the infection gets worse or does not improve, consult your doctor.

Do not use bandages that do not allow air circulation over the affected area unless otherwise directed by your doctor. A light, cotton-gauze dressing may be used to protect clothing.

Avoid getting this medication in your eyes, nose, or mouth or in large, open wounds.

Mupirocin nasal ointment:

Firstly, wash your hands well.

Apply approximately 1/2 of the ointment from the single-use tube directly from the tube into one nostril. Then apply the remainder of the ointment directly into the other nostril.

Close your nostrils by pressing the sides of the nose together and then releasing them. Do this over and over again for approximately one minute. You may also press the sides of the nose together and gently massage the nose. These methods will help spread the medicine throughout the inside of the nostrils.

Discard the tube after using. The tube only has enough medicine for one dose in each nostril.

Be careful not to touch your eyes.

Immediately after using the nose ointment, wash your hands to remove any medicine that may be on them.

What special precautions should I follow?

BEFORE TAKING MUPIROCIN:

Tell your doctor and pharmacist what prescription and non-prescription medications you are taking, especially chloramphenicol (Chloromycetin®). Do not use mupirocin topical if you have ever had an allergic reaction to it.

You may not be able to use mupirocin topical if you have a very large open wound. This medication contains polyethylene glycol, which may cause damage to your kidneys if too much drug is absorbed through your skin.

Mupirocin topical is in the FDA pregnancy category B. This means that it is unlikely to harm an unborn baby. Do not use mupirocin topical without first talking to your doctor if you are pregnant.

Additionally, mupirocin topical passes into breast milk and may affect a nursing infant. Do not use mupirocin topical without first talking to your doctor if you are breast-feeding a baby.

What should I do if I forget a dose?

Mupirocin nasal ointment:

If you miss a dose of this medicine, use it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Never take a double dose.

Mupirocin topical:

Apply the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed and apply only the regular amount of mupirocin topical. Do not use a double dose of this medication unless otherwise directed by your doctor.

What side effects can this medication cause?

Possible side effects from using mupirocin may include:

itching
burning

Tell your doctor if any of these symptoms are severe or do not go away:

burning
stinging
pain
itching
rash

If you experience any of the following symptoms, call your doctor immediately:

chest congestion
cough
ear pain
burning or stinging in the nose
change in taste
itching
sore throat
stuffy or runny nose

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Always store it at room temperature and away from excess heat and moisture (not in the bathroom).

Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

NOTE: do not refrigerate mupirocin nasal ointment.

In case of an emergency/overdose

An overdose of mupirocin topical is rare and no symptoms of an overdose are known. However, please consult a doctor if you suspect of an overdose.

If mupirocin topical gets in your eyes or mouth, rinse thoroughly with water.

Product Images

PICTURES OF MUPIROCIN PRODUCTS

Below you will find images and specific information on the principal types of mupirocin that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: BACTROBAN®
Strength(s):  2%
Imprint: BACTROBAN OINTMENT
Manufacturer: GLAXOSMITHKLINE

Name: CENTANY®
Strength(s):  2%
Imprint: CENTANY OINTMENT
Manufacturer: ORTHO PHARM.

Name: MUPIROCIN
Strength(s):  2%
Imprint: MUPIROCIN OINTMENT
Manufacturer: PERRIGO CO.

Name: MUPIROCIN
Strength(s):  2%
Imprint: MUPIROCIN OINTMENT
Manufacturer: TEVA USA

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